Vitamin K1

Generic Name: phytonadione (fye toe na DYE own)

Brand Names: Mephyton

What is Vitamin K1 (phytonadione)?

Phytonadione is a man-made form of vitamin K, which occurs naturally in the body.

Phytonadione is used to treat vitamin K deficiency and to treat certain bleeding or blood clotting problems.

Phytonadione may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Vitamin K1 (phytonadione)?

Never take phytonadione in larger amounts, or for longer than recommended by your doctor.

While using phytonadione, you may need blood tests at your doctor's office. Visit your doctor regularly.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using phytonadione.

What should I discuss with my healthcare provider before taking Vitamin K1 (phytonadione)?

You should not use phytonadione if you are allergic to it.

To make sure you can safely take phytonadione, tell your doctor if you have liver disease.

FDA pregnancy category C. It is not known whether phytonadione will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether phytonadione passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Vitamin K1 (phytonadione)?

Take exactly as prescribed by your doctor. Never take phytonadione in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

While using phytonadione, you may need blood tests at your doctor's office. Visit your doctor regularly.

Use phytonadione regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using phytonadione. Store in the original container at room temperature away from moisture, heat, and light. Keep the container tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Vitamin K1 (phytonadione)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Vitamin K1 (phytonadione) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  
  


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  dizziness;

  
  


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  fast or irregular heartbeats; or

  
  


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  increased sweating.

  
  

Call your doctor at once if you have a serious side effect such as:

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  feeling like you might pass out;

  
  


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  blue colored lips; or

  
  


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  trouble breathing.

  
  

Less serious side effects may include:

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  flushing (warmth, redness, or tingly feeling);

  
  


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  changes in your sense of taste;

  
  


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  sweating; or

  
  


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  dizziness.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Vitamin K1 (phytonadione)?

Tell your doctor about all other medicines you use, especially:

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  an antibiotic;

  
  


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  salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others.

  
  


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  a blood thinner such as anisindione (Miradon), heparin, or warfarin (Coumadin); or

  
  

This list is not complete and other drugs may interact with phytonadione. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Vitamin K1 resources

• Vitamin K1 Side Effects (in more detail)
• Vitamin K1 Use in Pregnancy & Breastfeeding
• Vitamin K1 Drug Interactions
• Vitamin K1 Support Group
• 0 Reviews for Vitamin K1 - Add your own review/rating

• Vitamin K1 Prescribing Information (FDA)


• Phytonadione Prescribing Information (FDA)


• Phytonadione Monograph (AHFS DI)


• Phytonadione MedFacts Consumer Leaflet (Wolters Kluwer)


• Mephyton Advanced Consumer (Micromedex) - Includes Dosage Information


• Mephyton Prescribing Information (FDA)


• Mephyton MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Vitamin K1 with other medications

• Hypoprothrombinemia, Anticoagulant Induced
• Hypoprothrombinemia, Not Associated with Anticoagulant Therapy
• Hypoprothrombinemia, Prophylaxis
• Vitamin K Deficiency

Where can I get more information?

• Your pharmacist can provide more information about phytonadione.

See also: Vitamin K1 side effects (in more detail)