Vfend I.V.

Generic Name: voriconazole (Intravenous route)

vor-i-KON-a-zole

Commonly used brand name(s)

In the U.S.

• Vfend I.V.

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antifungal

Chemical Class: Triazole

Uses For Vfend I.V.

Voriconazole injection is used to treat certain serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (including infections in the skin, stomach, kidney, bladder, and wounds). It may also be used to treat patients with serious fungal or yeast infections who cannot tolerate other types of medicine or who do not respond to other types of medicine.

This medicine is available only with your doctor's prescription.

Before Using Vfend I.V.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of voriconazole injection in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of voriconazole injection in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Astemizole


• Carbamazepine


• Cisapride


• Dihydroergotamine


• Dronedarone


• Ergoloid Mesylates


• Ergonovine


• Ergotamine


• Mephobarbital


• Mesoridazine


• Methylergonovine


• Methysergide


• Phenobarbital


• Pimozide


• Posaconazole


• Quinidine


• Rifabutin


• Rifampin


• Ritonavir


• Sirolimus


• Sparfloxacin


• St John's Wort


• Terfenadine


• Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abiraterone


• Acenocoumarol


• Alprazolam


• Amiodarone


• Amitriptyline


• Amoxapine


• Apomorphine


• Arsenic Trioxide


• Asenapine


• Azithromycin


• Boceprevir


• Bretylium


• Cabazitaxel


• Chloramphenicol


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clopidogrel


• Clozapine


• Crizotinib


• Cyclosporine


• Darunavir


• Dasatinib


• Delavirdine


• Desipramine


• Dicumarol


• Disopyramide


• Docetaxel


• Dofetilide


• Dolasetron


• Droperidol


• Efavirenz


• Erythromycin


• Everolimus


• Flecainide


• Fluconazole


• Fosphenytoin


• Gatifloxacin


• Gemifloxacin


• Glimepiride


• Granisetron


• Halofantrine


• Haloperidol


• Ibutilide


• Iloperidone


• Imipramine


• Ixabepilone


• Lapatinib


• Levofloxacin


• Lopinavir


• Lumefantrine


• Mefloquine


• Moxifloxacin


• Nevirapine


• Nilotinib


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Paliperidone


• Pazopanib


• Perflutren Lipid Microsphere


• Phenprocoumon


• Phenytoin


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinine


• Ranolazine


• Rivaroxaban


• Romidepsin


• Ruxolitinib


• Salmeterol


• Sildenafil


• Simvastatin


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Sunitinib


• Tacrolimus


• Telaprevir


• Telavancin


• Telithromycin


• Temsirolimus


• Tetrabenazine


• Ticagrelor


• Toremifene


• Trazodone


• Triazolam


• Trifluoperazine


• Trimipramine


• Vandetanib


• Vardenafil


• Vemurafenib


• Vinblastine


• Vincristine


• Vincristine Liposome


• Vinorelbine


• Warfarin


• Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amprenavir


• Atorvastatin


• Cerivastatin


• Desogestrel


• Diclofenac


• Dienogest


• Drospirenone


• Estradiol Cypionate


• Estradiol Valerate


• Ethinyl Estradiol


• Ethynodiol Diacetate


• Etonogestrel


• Etravirine


• Fentanyl


• Fosamprenavir


• Glipizide


• Glyburide


• Ibuprofen


• Levonorgestrel


• Lovastatin


• Medroxyprogesterone Acetate


• Meloxicam


• Mestranol


• Methadone


• Midazolam


• Nelfinavir


• Norelgestromin


• Norethindrone


• Norgestimate


• Norgestrel


• Omeprazole


• Oxycodone


• Saquinavir


• Tolbutamide


• Tretinoin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cancer treatment (e.g., chemotherapy), history of or


• Heart disease, history of or


• Mineral imbalance (e.g., low potassium, magnesium, or calcium in the blood) or


• Stem cell transplant—Use with caution. These conditions may increase your risk of having serious side effects.

• Heart rhythm problems (e.g., QT prolongation) or


• Liver disease (including cirrhosis) or


• Kidney disease or


• Pancreas problems—Use with caution. May make these conditions worse.

Proper Use of voriconazole

This section provides information on the proper use of a number of products that contain voriconazole. It may not be specific to Vfend I.V.. Please read with care.

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. It will be given slowly, so your IV tube will need to stay in place for up to 2 hours.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using Vfend I.V.

It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests will be needed to check for unwanted effects.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

You should not use any of the following medicines while you or your child are receiving this medicine:

• Astemizole (Hismanal®) or


• Carbamazepine (Tegretol®) or


• Cisapride (Propulsid®) or


• Ergot medicines (bromocriptine, dihydroergotamine, ergotamine, methysergide, Parlodel®, or Sansert®) or


• Phenobarbital (Luminal®) or


• Pimozide (Orap®) or


• Quinidine (Quinora®) or


• Rifabutin Mycobutin®) or


• Rifampin (Rifadin®, Rimactane®) or


• Ritonavir (Norvir®) or


• Sirolimus (Rapamune®) or


• St. John's wort or


• Terfenadine (Seldane®).

Using any of them together with this medicine may increase the chance of unwanted effects.

This medicine may cause some people to have changes in vision, such as blurred vision and seeing bright spots or wavy lines. Make sure you know how you react to this medicine before you drive (especially at night), use machines, or do anything else that could be dangerous if you have cannot see well.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause a serious type of allergic reaction called infusion reaction. This can be life-threatening and require immediate medical attention. Tell your doctor or nurse right away if you or your child have a fever, chills, flushing, itching or skin rash, shortness of breath, sweating, trouble with breathing, lightheadedness, fainting, or chest tightness within a few hours after you receive it.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Serious skin reactions can occur during treatment with this medicine. Stop using this medicine and check with your doctor right away if you or your child have any of the following symptoms while you are using this medicine: blistering, peeling, loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Vfend I.V. Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Rash

Less common

• Abdominal or stomach pain


• bloating or swelling of the face, arms, hands, lower legs, or feet


• blurred vision


• chills


• clay-colored stools


• confusion


• convulsions


• dark urine


• decreased urine


• dizziness


• dry mouth


• faintness or lightheadedness when getting up suddenly from a lying or sitting position


• fever


• flushing


• increased thirst


• irregular or pounding heartbeat


• itching


• loss of appetite


• mood or mental changes


• muscle pain or cramps


• muscle spasms or twitching


• nausea


• nervousness


• numbness or tingling in the hands, feet, or lips


• pounding in the ears


• rapid weight gain


• rash with flat lesions or small raised lesions on the skin


• shortness of breath


• slow or fast heartbeat


• sweating


• trembling


• unpleasant breath odor


• unusual tiredness or weakness


• vision changes


• vomiting of blood


• yellow eyes or skin

Rare

• Black, bloody, or tarry stools


• bleeding gums


• blood in the eye


• blood in the urine or stools


• chest pain


• eye pain


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• redness in the white part of the eyes


• seeing things that are not there


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• trouble breathing with activity


• unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Diarrhea


• headache


• nausea


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Vfend I.V. side effects (in more detail)

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More Vfend I.V. resources

• Vfend I.V. Side Effects (in more detail)
• Vfend I.V. Use in Pregnancy & Breastfeeding
• Drug Images
• Vfend I.V. Drug Interactions
• Vfend I.V. Support Group
• 1 Review for Vfend I.V. - Add your own review/rating

Compare Vfend I.V. with other medications

• Aspergillosis, Invasive
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• Fungal Meningitis
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